Thermo Fisher Scientific BHC110/LSD1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human LSD1 for IHC and IHC-P applications. Recognizes residues 50–100 of FAD-binding protein BRAF35-HDAC complex. High specificity, affinity-purified, liquid form, stored at 4°C. For research use only.
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Thermo Fisher Scientific BHC110/LSD1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 50 and 100 of human FAD-binding protein BRAF35-HDAC complex 110 kDa (lysine-specific histone demethylase 1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Orangutan and Gorilla
Target Information
LSD1 is a histone demethylase that specifically demethylates Lys-4 of histone H3, a tag for epigenetic transcriptional activation, acting as a corepressor. It contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. LSD1 is part of several histone deacetylase complexes and silences genes via demethylation. It oxidizes substrates through FAD, generating imine intermediates that are hydrolyzed. LSD1 demethylates mono- and tri-methylated Lys-4 of histone H3 and may repress neuronal genes. It requires RCOR1/CoREST to demethylate H3 Lys-4 on nucleosomes. LSD1 can also demethylate Lys-9 of histone H3, leading to derepression of androgen receptor target genes. Mutations in this gene can result in cleft palate, psychomotor retardation, and distinctive facial features.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: IHC-00122_LSD1_O60341-1_Rabbit.svg, IHC-00122_LSD1_O60341-1_Rabbit_PDP.jpeg)
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