Thermo Fisher Scientific Blood Group Lewis a Polyclonal Antibody
인간 Blood Group Lewis a 항원을 인식하는 Rabbit Polyclonal Antibody로 다양한 면역실험(WB, IHC, ICC, ELISA)에 사용 가능. Protein A로 정제된 액상형 제품이며, 고농도(1 mg/mL)로 안정적 보관(-20°C) 가능. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Blood Group Lewis a (amino acids 201–300) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids synthesized by exocrine epithelial cells and circulating in body fluids. These glycosphingolipids play roles in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are absorbed to red blood cells, forming the Lewis phenotype.
This gene belongs to the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the final step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)- and alpha(1,4)-fucosyltransferase activities. Mutations in this gene cause Lewis antigen-negative phenotypes. Multiple alternatively spliced variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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