Thermo Fisher Scientific BLVRA/Biliverdin Reductase Polyclonal Antibody
BLVRA/Biliverdin Reductase 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 마우스, 랫트 반응성. 다양한 IHC, ICC, Flow Cytometry, ELISA 실험에 적합. 고순도 Protein A 정제, 안정적인 액상 형태로 연구용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human BLVRA/Biliverdin Reductase (amino acids 161–260) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Biliverdin reductase (BLVR) is a ubiquitously expressed cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The process begins with heme oxygenase converting heme to iron, carbon monoxide, and biliverdin. BLVR is unique for its dual pH/dual cofactor dependency, using NADH (pH 6.7) or NADPH (pH 8.7) as electron donors.
Two isoforms exist:
- BLVRA (biliverdin-IX alpha-reductase) – major component in adult human liver
- BLVRB (biliverdin-IX beta-reductase) – predominant in fetal liver
Bilirubin, the product of BLVR activity, functions as an antioxidant but also acts as a neurotoxin causing kernicterus. It inhibits kinase activity and enzymes such as protein kinase C and NADPH oxidase.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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