Thermo Fisher Scientific SYK Polyclonal Antibody
Rabbit polyclonal antibody against human Spleen Tyrosine Kinase (SYK). Suitable for IHC and IHC (Paraffin) applications. Affinity purified, liquid form, 0.25 mg/mL. Predicted cross-reactivity with primates. For research use only.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 250 and 300 of Human Spleen Tyrosine Kinase (SYK) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and Crab-eating macaque
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer.
Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, providing docking sites for signaling pathways such as calcium mobilization, cytoskeleton remodeling, and transcription of specific genes.
Syk binds to receptor assemblies through its SH2 domains interacting with ITAM motifs phosphorylated by Src-family kinases, which also activate Syk by phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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