Thermo Fisher Scientific Cyclin B1 Monoclonal Antibody (2E6)
Cyclin B1 단백질을 인식하는 Rabbit Monoclonal 항체로, Western blot, IHC, ICC 등 다양한 응용에 적합합니다. 세포주기 G2/M 전이 조절 연구에 활용되며, 액상 형태로 제공되어 -20°C에서 보관합니다. 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2E6 |
| Immunogen | Recombinant human Cyclin B1 protein (around N-terminal 150aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
Cyclins bind to and regulate the activity of Cyclin-dependent protein kinases (CDKs). Cyclin B1 (CCNB1) is a regulatory protein essential for controlling the cell cycle at the G2/M transition. It forms a complex with p34 (cdc2) to create the maturation-promoting factor (MPF). Two alternative transcripts exist: one constitutively expressed and one cell cycle-regulated, predominantly during the G2/M phase. Cyclin B1 accumulates during G2 phase and is degraded at the end of mitosis via APC-dependent mechanisms. Overexpression of Cyclin B1 has been observed in various cancers, including breast, prostate, and non-small cell lung cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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