Thermo Fisher Scientific Cyclin D3 Monoclonal Antibody (4A8)
Cyclin D3 단백질을 인식하는 Rabbit monoclonal antibody(클론 4A8). Western blot과 Immunocytochemistry에 사용 가능. 세포 주기 조절 연구 및 CDK 관련 단백질 분석에 적합. 액상 형태, 1 mg/mL 농도, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A8 |
| Immunogen | Recombinant human Cyclin D3 protein, around C-terminal 200aa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
Target Information
The protein encoded by this gene belongs to the highly conserved cyclin family, characterized by periodic changes in protein abundance during the cell cycle. Cyclins regulate CDK kinases, and distinct cyclins display specific expression and degradation patterns that coordinate mitotic events. Cyclin D3 forms a complex with CDK4 or CDK6, acting as a regulatory subunit required for the G1/S transition. It interacts with and phosphorylates tumor suppressor protein Rb. CDK4 activity associated with Cyclin D3 is necessary for progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms exist. Diseases associated with CCND3 include Retinoblastoma and Plasma Cell Leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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