Thermo Fisher Scientific ACE Polyclonal Antibody

Thermo Fisher Scientific ACE Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000
• Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Chimpanzee (98%).
• Positive Control: Mouse lung.
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes—the somatic form and the testicular form—that are equally active. Multiple additional alternatively spliced variants have been identified but their full-length nature has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.