Thermo Fisher Scientific SARS-CoV-2 Spike Protein S1/S2 Polyclonal Antibody
SARS-CoV-2 Spike 단백질 S1/S2를 인식하는 Rabbit Polyclonal Antibody로, WB, ICC/IF, ELISA 등에 사용 가능. 항원 친화 크로마토그래피로 정제된 고순도 항체이며, PBS 버퍼 내 0.02% sodium azide 포함. 연구용으로 바이러스 단백질 분석에 적합.
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- PA5112048
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 4 publications |
| Immunocytochemistry (ICC/IF) | 1 µg/mL | View publications |
| Flow Cytometry (Flow) | - | View 3 publications |
| ELISA | 1 µg/mL | View 1 publication |
| Neutralization (Neu) | - | View 1 publication |
| Functional Assay | - | View 1 publication |
| In vitro Assay | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Virus |
| Published Species | Hamster, Human, Mouse, Virus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide corresponding to 20 amino acids near the carboxy terminus of SARS-CoV-2 (COVID-19, 2019-nCoV) Spike glycoprotein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2866784 |
Product Specific Information
The immunogen is located within the last 50 amino acids of SARS-CoV-2 (COVID-19, 2019-nCoV) Spike protein.
Predicted reactivity based on immunogen sequence: SARS-CoV Spike proteins (100%).
Target Information
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), also known as 2019-nCoV, causes illnesses ranging from mild cold symptoms to severe respiratory distress and death.
The CoV Spike (S) protein plays a critical role in viral attachment, fusion, and entry, serving as a key target for antibody development, entry inhibitors, and vaccines.
The receptor-binding domain (RBD, S-RBD) in SARS-CoV-2 Spike protein binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors, showing higher affinity than SARS-CoV RBD.
- S1 subunit (amino acids 14–685): responsible for receptor binding
- S2 subunit (amino acids 686–1273): responsible for membrane fusion
- S-ECD: extracellular domain of the Spike protein
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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