Thermo Fisher Scientific Integrin beta 1 (CD29) VHH-8His-Cys-tag Recombinant Alpaca Monoclonal Antibody (SAA1306)

Applications

• ELISA (ELISA): Assay-dependent

Product Specifications

Product Specific Information

• Compatible with Direct ELISA

Target Information

ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein widely expressed by various cells including all leukocytes.
It forms non-covalently linked heterodimers with at least six different alpha chains (α1–α6, CDa–f), determining the binding properties of beta1 (VLA) integrins.
ITGB1 functions as a cell adhesion molecule on platelets, as the common beta subunit of the very late activation antigen (VLA), and as a component of multiple protein complexes binding to extracellular matrix proteins.

Decreased expression of ITGB1 correlates with multidrug resistance in tumor cells exposed to anti-tumor drugs. It is up-regulated in leukocytes during emigration and extravascular migration, playing a critical role in immune cell trafficking from blood to tissue.
Additionally, ITGB1 regulates tissue damage and disease symptoms related to inflammatory bowel disease. Through ITGB1-dependent mechanisms, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle cells in response to IL-1β.

More than eight beta subunits with numerous splice variant isoforms have been identified in mammals. Two major forms of integrin beta1 exist: beta1A and beta1D, differing by 13 amino acids. Their distribution patterns in adult tissues are mutually exclusive — beta1A is present in all tissues except cardiac and skeletal muscle, which express the beta1D variant.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.