Thermo Fisher Scientific HTRA1 Polyclonal Antibody
HTRA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 응용 가능. 인간에 반응하며, 세포 성장 조절 및 TGF-beta 신호 억제 연구에 활용. 연구용으로만 사용.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
- Publications: View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Bacteria |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 381–412 amino acids from the C-terminal region of human HtrA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Size-exclusion, Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2122813 |
Product Specific Information
This antibody is predicted to react with rat based on sequence homology.
Target Information
HtrA1 is a 51 kDa protein belonging to the highly conserved mammalian HtrA serine protease family. It is a human homolog of bacterial HtrA and includes:
- Secretory signal sequence
- IGFBP-binding domain
- Kazal-type serine-protease inhibitor domain (N-terminus)
- Trypsin-like serine/protease domain and PDZ domain (C-terminus)
HtrA1 plays a crucial role in cell growth regulation, inhibits TGF-beta signaling, and is involved in various physiological processes. It is up-regulated in the placenta during pregnancy, contributing to implantation and placental physiology. HtrA1 regulates IGF availability by cleaving IGF-binding proteins, acts as a tumor suppressor, and is down-regulated in ovarian cancers and melanomas. Its expression is implicated in osteoarthritis, suggesting therapeutic potential. Northern blot analysis shows high expression in placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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