Thermo Fisher Scientific PSMC4 Polyclonal Antibody

Thermo Fisher Scientific PSMC4 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:2,000
• Immunoprecipitation (IP): 1–5 µL/mg of lysate

Product Specifications

Target Information

The 26S proteasome is a multicatalytic proteinase complex composed of two major complexes: a 20S core and a 19S regulator.

• 20S core: Four rings of 28 non-identical subunits (two rings of 7 alpha and two rings of 7 beta subunits).
• 19S regulator: Contains a base (6 ATPase and 2 non-ATPase subunits) and a lid (up to 10 non-ATPase subunits).
  Proteasomes are abundant in eukaryotic cells and function in ATP/ubiquitin-dependent peptide cleavage via a non-lysosomal pathway.
  The immunoproteasome variant processes class I MHC peptides.
  This gene encodes one of the ATPase subunits of the triple-A family, which exhibit chaperone-like activity.
  It interacts with an orphan nuclear hormone receptor and with gankyrin, a liver oncoprotein.
  Two transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.