Thermo Fisher Scientific PCDHGC3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  IKDNGEPSLS TTATLTVSVT EDSPEARAEF PSGSAPREQK KNLTFYLLLS
• For short term use, store at 2–8°C up to 1 week.
• For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted homology:
  Cow: 92%; Guinea Pig: 85%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%

Target Information

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression.
The gamma gene cluster includes 22 genes divided into 3 subfamilies:

• Subfamily A: 12 genes
• Subfamily B: 7 genes and 2 pseudogenes
• Subfamily C: 3 genes

Each variable region exon encodes the extracellular region with six cadherin ectodomains and a transmembrane region, while the constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins are likely involved in establishing specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.