Thermo Fisher Scientific CHCHD6 Polyclonal Antibody
인간 CHCHD6 단백질을 인식하는 Thermo Fisher의 rabbit polyclonal 항체로, Western blot에 최적화되어 있습니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 0.02% sodium azide를 포함한 액상 형태입니다. 세포 내 미토콘드리아 연구 및 단백질 발현 분석에 적합합니다.
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Thermo Fisher Scientific CHCHD6 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 17 amino acid peptide near the amino terminus of human CHCHD6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551838 |
Product Specific Information
- Suggested positive control: SK-N-SH cell lysate
- Blocking peptide: PEP-1528
Target Information
CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain. It interacts with mitochondrial proteins such as mitofilin, SAM50, metaxins 1 and 2, and CHCHD3.
Knockdown of CHCHD6 causes severe defects in mitochondrial cristae morphology, reduced cell growth, ATP production, and oxygen consumption. It also affects mitofilin protein levels, suggesting coordinate regulation between CHCHD6 and mitofilin.
In human cancer cells, CHCHD6 knockdown increases sensitivity to genotoxic anticancer drugs, indicating its potential as a therapeutic anti-tumor target.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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