Thermo Fisher Scientific PSMD7 Polyclonal Antibody
Thermo Fisher Scientific의 PSMD7 Polyclonal Antibody는 인간 PSMD7 단백질(26S proteasome sub유닛)을 인식하는 rabbit polyclonal 항체입니다. Western blot, IHC, IP 등 다양한 응용에 적합하며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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- A303828Ax (2개 옵션)
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 150 and 200 of Human Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with D. melanogaster and Bovine.
Target Information
Proteolytic degradation is critical for maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, receptor modulation, ion channel regulation, cell cycle control, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most proteins in eukaryotic cytosol and nucleus, while others are degraded via the vacuolar pathway (endosomes, lysosomes, ER).
The 26S proteasome is an ATP-dependent, multisubunit complex (~2.5 MDa) consisting of a 20S proteolytic core and 19S regulatory subunits. The 19S subunits recognize ubiquitinated proteins and facilitate unfolding and translocation into the 20S core.
Defects in this pathway are linked to diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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