Thermo Fisher Scientific GUCY1A3 Polyclonal Antibody
Thermo Fisher Scientific의 GUCY1A3 Polyclonal Antibody는 인간, 마우스, 랫트에 반응하는 토끼 유래 IgG 항체입니다. Western blot과 IHC(P)에서 검증되었으며, 고순도의 액상 제형으로 제공됩니다. Affinity chromatography로 정제되어 높은 특이성과 재현성을 제공합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GUCY1A3 (Accession Q02108), corresponding to amino acid residues M591–E641. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853720 |
Product Specific Information
Antibody detects endogenous levels of total GCS alpha-1.
Target Information
Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase: a soluble form (GCS or sGC), which acts as a receptor for nitric oxide, and a membrane-bound receptor form (GC), which functions as a peptide hormone receptor.
The GC-C protein comprises an extracellular domain, a single transmembrane domain, and a cytoplasmic region with kinase-like and catalytic domains. It exists as two glycosylated forms: a 130 kDa precursor in the endoplasmic reticulum and a 145 kDa mature form on the plasma membrane.
Ligand binding to GC-C promotes cGMP accumulation. GC-C serves as the receptor for heat-stable enterotoxins from pathogenic E. coli strains causing secretory diarrhea, and also binds guanylin and uroguanylin peptides that regulate renal function in response to salt intake.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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