Thermo Fisher Scientific IL-10 Monoclonal Antibody (945A5A10), Biotin
인간 IL-10을 인식하는 Biotin 접합 단클론 항체로, Sandwich ELISA 검출용으로 권장됩니다. Mouse IgG1, kappa 아이소타입이며 Protein A로 정제된 액상 형태입니다. 4°C에서 보관하며 연구용으로만 사용 가능합니다.
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Applications
ELISA
- Tested Dilution: Assay-dependent
- Publications: View 7 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Non-human primate, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 945A5A10 |
| Immunogen | Recombinant human IL-10 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 5 mg/mL BSA |
| Contains | 0.5 mg/mL sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536289 |
Product Specific Information
This product is recommended as a detection antibody in Sandwich ELISA applications.
Target Information
IL-10 encodes a cytokine primarily produced by monocytes, with some production by lymphocytes. It regulates immune responses and inflammation by down-regulating Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. IL-10 enhances B cell survival, proliferation, and antibody production, blocks NF-kappa B activity, and participates in JAK-STAT signaling regulation. Knockout studies indicate its essential role as an immunoregulator in the intestinal tract. Mutations in IL10 are linked to increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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