Thermo Fisher Scientific IL-10 Monoclonal Antibody (945A5D11)

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: -
• Publications: View 1 publication

ELISA

• Tested Dilution: Assay-dependent
• Publications: View 8 publications

Product Specifications

Product Specific Information

This product is recommended as a capture antibody in Sandwich ELISA applications.

Target Information

IL-10 encodes a cytokine primarily produced by monocytes, with additional production by lymphocytes. It plays a key role in immunoregulation and inflammation by:

• Down-regulating Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages
• Enhancing B cell survival, proliferation, and antibody production
• Blocking NF-kappa B activity
• Regulating the JAK-STAT signaling pathway

Knockout studies in mice indicate IL-10 is essential for intestinal immune regulation. Mutations in IL10 are linked to increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.