Thermo Fisher Scientific SENP8 Polyclonal Antibody
Human SENP8 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태. NEDD8 경로 조절 연구에 적합하며, 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SENP8. Recombinant protein control fragment (Product #RP-95846). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2790474 |
Product Specific Information
Immunogen sequence:
RKGDKLAFVE EKAPAQQNSY DCGMYVICNT EALCQNFFRQ QTESLLQLLT PAYITKKRGE WKDLITTLAK
Target Information
SENP8 (Cysteine protease FKSG8; DEN1; FKSG8; HsT17512; NEDP1; PRSC2; SUMO/sentrin specific protease family member 8) is a novel cysteine protease belonging to the ULP family of deubiquitinases. Members of the ULP family consist of a C-terminal core catalytic domain and N-terminal extensions determining substrate specificity.
SENP8, a 24 kDa protein, plays a major role in regulating the NEDD8 pathway. It processes preNEDD8 to its mature form and deconjugates NEDD8 from substrates such as Cullins and p53. SENP8 may help prevent accumulation of hyper-neddylated cullin and maintain mono-neddylated cullin levels, enhancing ubiquitination efficiency by SCF ubiquitin ligases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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