Thermo Fisher Scientific Aminoacylase Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000–1:2,500

Product Specifications

Product Specific Information

Immunogen sequence:
QGMELFVQRP EFHALRAGFA LDEGIANPTD AFTVFYSERS PWWVRVTSTG RPGHASRFME DTAAEKLHKV VNSILAFRE

Target Information

ACY1 encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group. It functions in the catabolism and salvage of acylated amino acids.
This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression is often reduced or undetectable in SCLC cell lines and tumors.
The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart and represents the first member of a new family of zinc-binding enzymes.
Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by CNS defects and increased urinary excretion of N-acetylated amino acids.
Alternative splicing results in multiple transcript variants, and read-through transcription exists between this gene and the upstream ABHD14A gene. A related pseudogene is located on chromosome 18.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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