Thermo Fisher Scientific KCNE1 Monoclonal Antibody (2A6)
KCNE1 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체(2A6). ELISA 및 IP에 사용 가능하며 인간 시료에 반응. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용으로만 사용.
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Applications
ELISA
- Tested Dilution: 3 ng/mL
Immunoprecipitation (IP)
- Tested Dilution: 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A6 |
| Immunogen | KCNE1 (AAH36452, 1–105 a.a) full-length recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MILSNTTAVT PFLTKLWQET VQQGGNMSGL AHRSPRSGDG KLEALYVLMV LGFFGFFTLG IMLSYIRSKK LEHSNDPFNV YIESDAWQEK DKAYVQARVL ESYRS
Target Information
Kcne1 is a member of the voltage-gated potassium (Kv) channels, representing one of the most complex classes of voltage-gated ion channels. Kv channels regulate neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
The Kcne1 gene encodes a membrane protein similar to the KCNE1 gene product, a member of the potassium channel, voltage-gated, isk-related subfamily. Kcne1, an intronless gene, is deleted in AMME contiguous gene syndrome and may contribute to cardiac and neurologic abnormalities in the syndrome. Functionally, Kcne1 acts as a potassium channel ancillary subunit essential for generating native K(+) currents through heteromeric ion channel complexes with Kv channel alpha subunits. It also serves as an inhibitory beta-subunit of the repolarizing cardiac potassium ion channel KCNQ1.
Diseases associated with KCNE1 include Jervell and Lange-Nielsen Syndrome 2 and Long QT Syndrome 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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