Thermo Fisher Scientific KIAA0196 Polyclonal Antibody
Rabbit polyclonal antibody against human KIAA0196 (Strumpellin). Validated for ICC/IF applications. Antigen affinity purified, supplied in PBS with 40% glycerol. High sequence identity with mouse and rat orthologs. For research use only.
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Applications and Tested Dilution
- Immunocytochemistry (ICC/IF): 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human KIAA0196. Recombinant protein control fragment (Product #RP-107779) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663199 |
Product Specific Information
Immunogen sequence:
HRGLIFNPRAK PSELMPKLKE LGATMDGFHR SFEYIQDYVN IYGLKIWQEE VSRIINYNVE QECNNFLRTK IQDWQSMYQS THIPIPKFTP VD
Highest antigen sequence identity to the following orthologs:
- Mouse: 98%
- Rat: 98%
Target Information
This gene encodes a 134 kDa protein named Strumpellin, predicted to have multiple transmembrane domains and a spectrin-repeat-containing domain. It is ubiquitously expressed, with highest expression in skeletal muscle. Strumpellin is associated with Strumpell disease, a form of hereditary spastic paraplegia (HSP). These disorders are characterized by progressive lower extremity spasticity due to axonal degeneration in corticospinal tracts. Over 30 loci (SPG1–33) are implicated in hereditary spastic paraplegia diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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