Thermo Fisher Scientific NOC3L Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
GSGALKPELSR RSATELFEAY SMAEMTFNPP VESSNPKIKG KFLQGDSFLN EDLNQLIKRY SSEVATES

Highest antigen sequence identity to the following orthologs:

• Mouse: 80%
• Rat: 83%

Target Information

GADD 153, a growth arrest and DNA damage-inducible gene, encodes a C/EBP-related nuclear protein. This protein has also been designated C/EBP-homologous protein (CHOP-10 or C/EBP zeta). GADD 153 expression is induced by various cellular stresses, including nutrient deprivation and metabolic perturbations. It functions to block cells in G1 to S phase during cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD 153 dimers away from classical C/EBP binding sites, recognizing instead unique nonclassical sites. Thus, GADD 153 acts as a negative modulator of C/EBP-like proteins in certain terminally differentiated cells.

GADD 153 belongs to the CBF/MAK21 family, which also includes NOC2L, NOC3L, and NOC4L. NOC3L, also designated factor for adipocyte differentiation 24 (Fad24), promotes adipogenesis by controlling DNA replication during the early stages of mitotic clonal expansion (MCE).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.