Thermo Fisher Scientific Junctophilin 4 Polyclonal Antibody
Junctophilin 4 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등에 사용 가능. Human, Mouse, Rat에 반응하며, Protein A 정제 및 1 mg/mL 농도의 액상 형태. 신경계 연구 및 세포막-소포체 결합 복합체 연구에 적합.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Junctophilin 4 (amino acids 301–400) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are common in excitable cells and mediate communication between surface and intracellular ion channels.
Junctophilins (JPs) are essential components of these complexes, consisting of a hydrophobic C-terminal segment spanning the ER/SR membrane and a cytoplasmic domain with affinity for the PM.
Four tissue-specific JP subtypes are known:
- JPH1: Expressed in skeletal muscle
- JPH2: Present in all muscle cell types
- JPH3 and JPH4: Predominantly expressed in the brain
In the CNS, JPH3 and JPH4 contribute to subsurface cistern formation in neurons. Mice lacking both subtypes show impaired learning, memory deficits, and abnormal neural functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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