Thermo Fisher Scientific PDCD1 Monoclonal Antibody (OTI13A3), TrueMAB

Applications

Flow Cytometry (Flow)

• Tested Dilution: 1:50

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Cell-mediated immune responses are initiated by T lymphocytes stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC).
Activated T cells express receptors such as PD-1 (PDCD-1) that mediate inhibitory signals from APCs.
PD-1 binds to ligands PDL-1 and PDL-2, generating inhibitory signals that suppress immune activation in the absence of danger signals (e.g., LPS).
PD1-deficient mice exhibit hyperactivated immune systems and autoimmune phenotypes.
Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.