Thermo Fisher Scientific Human CRTH2 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 13 amino acids near the carboxy terminus of human PTGDR2.
PEP-1545 can be used as a blocking peptide with polyclonal antibody PA5-34502.

Target Information

CRTH2 (GPR44) is a chemoattractant receptor-homologous molecule expressed on Th2 cells that is an identified receptor for prostaglandin D2 (PGD2) and prostaglandin D receptor.
CRTH2 mediates chemotaxis of Th2 cells and eosinophils to PGD2 and is thought to be a key receptor in allergic responses.
CRTH2 knockout mice exhibit enhanced eosinophil recruitment and higher IL-5 and IL-3 production, indicating a role in restricting eosinophilia and allergic response in vivo.
CRTH2 is a G protein-coupled receptor selectively expressed in Th2 lineage cells, and has been reported in the CNS, peripheral tissues, and activated Th2 cells.
Two transcripts have been identified:

• 3.5 kb transcript in thalamus, frontal cortex, pons, hippocampus
• 3.4 kb transcript in fetal liver, leukocytes, thymus
  CRTH2 expression is associated with activated allergen-responsive Th2 cells, suggesting its pivotal role in Th2-type immune reactions.
  At least two isoforms exist. SNPs in the 3′ UTR of CRTH2 gene are linked to asthma susceptibility.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.