Thermo Fisher Scientific alpha-2c Adrenergic Receptor Polyclonal Antibody
Alpha-2C 아드레날린 수용체를 인식하는 Thermo Fisher의 Rabbit Polyclonal Antibody. 인간 및 비인간 영장류 반응성. 항원 친화 크로마토그래피로 정제된 액상형 항체. IHC(P)에서 15–30 µg/mL 농도로 사용 가능. 연구용으로만 사용.
- 카탈로그번호
- PA533332
- 판매단위
- pk
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Thermo Fisher Scientific alpha-2c Adrenergic Receptor Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 15–30 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 18 amino acid peptide from 2nd extracellular domain of human ADRA2C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550715 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon, Monkey (100%)
Mouse, Rat, Panda, Bovine, Dog, Guinea pig (94%)
Hamster (89%)
Target Information
Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include three highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors play a critical role in regulating neurotransmitter release from sympathetic nerves and adrenergic neurons in the central nervous system.
Mouse studies revealed that both alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons.
The alpha2A subtype inhibits transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulates neurotransmission at lower levels of nerve activity.
This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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