Thermo Fisher Scientific CD11b/c Monoclonal Antibody (OX-42), FITC

Applications

• Flow Cytometry (Flow): 0.1 µg/1x10^6 cells
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Product Specifications

Additional Formats

• Unconjugated
• APC
• Biotin
• PE
• Request custom conjugation

Target Information

Integrins are heterodimeric integral membrane proteins composed of an alpha and a beta chain. CD11b is involved in adhesive interactions of monocytes, macrophages, and granulocytes, mediating uptake of complement-coated particles. It is identical to CR3, the receptor for the iC3b fragment of complement component 3.
CD11b also serves as a receptor for fibrogen, factor X, and ICAM1, recognizing P1 and P2 peptides of the fibrogen gamma chain. The Mac1 CD11b antigen is expressed on macrophages, granulocytes, NK cells, and blood monocytes, and is used as a microglial marker in nervous tissue.
CD11c encodes the integrin alpha X chain protein, which combines with beta 2 (ITGB2) to form CR4, a leukocyte-specific integrin. The αXβ2 complex overlaps with αMβ2 integrin in neutrophil and monocyte adherence and complement-coated particle phagocytosis.
Mutations in CD11b/c are associated with systemic lupus erythematosus 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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