Thermo Fisher Scientific CD11b/c Monoclonal Antibody (OX-42), FITC
Thermo Fisher Scientific CD11b/c Monoclonal Antibody (OX-42), FITC는 Rat CD11b/c 항원을 인식하는 마우스 IgG2a 단클론 항체입니다. Flow Cytometry에 적합하며, FITC 형광 표지로 498/517 nm의 발광 특성을 가집니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Flow Cytometry (Flow): 0.1 µg/1x10^6 cells
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Published Species | Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX-42 |
| Immunogen | Rat Peritoneal Macrophages |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% Sodium Azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles; store in the dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538899 |
Additional Formats
Target Information
Integrins are heterodimeric integral membrane proteins composed of an alpha and a beta chain. CD11b is involved in adhesive interactions of monocytes, macrophages, and granulocytes, mediating uptake of complement-coated particles. It is identical to CR3, the receptor for the iC3b fragment of complement component 3.
CD11b also serves as a receptor for fibrogen, factor X, and ICAM1, recognizing P1 and P2 peptides of the fibrogen gamma chain. The Mac1 CD11b antigen is expressed on macrophages, granulocytes, NK cells, and blood monocytes, and is used as a microglial marker in nervous tissue.
CD11c encodes the integrin alpha X chain protein, which combines with beta 2 (ITGB2) to form CR4, a leukocyte-specific integrin. The αXβ2 complex overlaps with αMβ2 integrin in neutrophil and monocyte adherence and complement-coated particle phagocytosis.
Mutations in CD11b/c are associated with systemic lupus erythematosus 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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