Thermo Fisher Scientific SERPINF1 Monoclonal Antibody (OTI1F7), TrueMAB
SERPINF1(PEDF) 단백질을 인식하는 Thermo Fisher Scientific의 TrueMAB 단일클론 항체로 인간 시료에서 반응. WB 검증 완료, 비결합형 형태로 제공되며 재수화 및 결합 실험에 적합. 신경보호 및 항혈관신생 연구용.
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Thermo Fisher Scientific SERPINF1 Monoclonal Antibody (OTI1F7), TrueMAB
Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F7 |
| Immunogen | Full-length human recombinant SERPINF1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
PEDF (SERPINF1) is a noninhibitory serpin exhibiting neurotrophic, anti-angiogenic, and anti-tumorigenic properties.
It is a 50 kDa glycoprotein secreted in various tissues. PEDF induces apoptosis in proliferating endothelial cells and inhibits angiogenic factors such as VEGF and FGF-2.
Its neuroprotective effects stem from suppression of neuronal apoptosis induced by oxidative or excitotoxic stress.
PEDF binds to a lipase-linked receptor (PEDF-R) with high affinity, the only known serpin signaling receptor.
These properties suggest PEDF as a potential therapeutic target for vasculature-related neurodegenerative diseases (e.g., AMD, PDR) and angiogenesis-related cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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