Thermo Fisher Scientific FNTB Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
MASPSSFTYY CPPSSSPVWS EPLYSLRPEH ARERLQDDSV ETVTSIEQAK VEEK

Highest antigen sequence identity to the following orthologs:

• Mouse: 96%
• Rat: 98%

Target Information

Eukaryotic cells contain three types of prenyltransferases that attach either a farnesyl group (15 carbons) or a geranylgeranyl group (20 carbons) in thioether linkage to C-terminal cysteine residues in various proteins. These posttranslational modifications enable membrane localization of proteins lacking transmembrane domains.

CAAX farnesyltransferase (FTase) attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins ending in the CAAX box, where C is cysteine, A is usually an aliphatic amino acid, and X is typically methionine or serine.

The gene for the beta subunit of CAAX farnesyltransferase (FNTB) is located at 14q23–q24, identified by Southern blot hybridization, PCR analyses, and fluorescence chromosomal in situ hybridization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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