Thermo Fisher Scientific Plasma Kallikrein Polyclonal Antibody
Thermo Fisher Scientific의 Plasma Kallikrein Polyclonal Antibody는 마우스 반응성의 염소 유래 IgG 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA547334
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunoprecipitation (IP) | 25 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse Kallikrein/KLKB1 Gly20-Ala638 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609106 |
Product Specific Information
In direct ELISAs and Western blots, approximately 25% cross-reactivity with recombinant human KLKB1 is observed and less than 1% cross-reactivity with recombinant human KLK1, 3, 5, 7, 13, and 14 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation, and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa through cleavage of an internal Arg-Ile bond.
Plasma kallikrein is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain contains four tandem repeats of 90–91 amino acids, each forming an apple domain, essential for surface-dependent pro-coagulant activity. The light chain contains the catalytic domain homologous to the trypsin family of serine proteases.
Deficiency of plasma prekallikrein causes prolonged activated partial thromboplastin time in patients.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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