Thermo Fisher Scientific GCN1L1 Polyclonal Antibody
Thermo Fisher Scientific의 GCN1L1 폴리클로날 항체는 인간 GCN1L1 단백질을 대상으로 한 토끼 IgG 항체로, Western blot과 ELISA에 적합합니다. 고순도 친화 크로마토그래피 정제 제품으로, 액상 형태이며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 2462–2671 of human GCN1L1 (NP_0068271) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.66 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805260 |
Product Specific Information
Immunogen sequence:
LSAVLQQCLL ADVSGIDWMV RHGRSLALSV AVNVAPGRLC AGRYSSDVQE MILSSATADR IPIAVSGVRG MGFLMRHHIE TGGGQLPAKL SSLFVKCLQN PSSDIRLVAE KMIWWANKDP LPPLDPQAIK PILKALLDNT KDKNTVVRAY SDQAIVNLLK MRQGEEVFQS LSKILDVASL EVLNEVNRRS LKKLASQADS TEQVDDTILT
Positive Samples: OVCAR3, U-87MG, HepG2, HeLa
Target Information
Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 acts as a chaperone to facilitate delivery of uncharged tRNAs to the tRNA-binding domain of EIF2AK4/GCN2, stimulating its kinase activity. Participates in repression of global protein synthesis and activation of gene-specific mRNA translation, such as ATF4, by promoting EIF2AK4/GCN2-mediated phosphorylation of eIF-2-alpha (EIF2S1) on Ser-52, enabling ATF4-mediated reprogramming of amino acid biosynthetic gene expression.
[UniProt]
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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