Thermo Fisher Scientific GCN1L1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

ELISA

• Tested Concentration: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
LSAVLQQCLL ADVSGIDWMV RHGRSLALSV AVNVAPGRLC AGRYSSDVQE MILSSATADR IPIAVSGVRG MGFLMRHHIE TGGGQLPAKL SSLFVKCLQN PSSDIRLVAE KMIWWANKDP LPPLDPQAIK PILKALLDNT KDKNTVVRAY SDQAIVNLLK MRQGEEVFQS LSKILDVASL EVLNEVNRRS LKKLASQADS TEQVDDTILT

Positive Samples: OVCAR3, U-87MG, HepG2, HeLa

Target Information

Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 acts as a chaperone to facilitate delivery of uncharged tRNAs to the tRNA-binding domain of EIF2AK4/GCN2, stimulating its kinase activity. Participates in repression of global protein synthesis and activation of gene-specific mRNA translation, such as ATF4, by promoting EIF2AK4/GCN2-mediated phosphorylation of eIF-2-alpha (EIF2S1) on Ser-52, enabling ATF4-mediated reprogramming of amino acid biosynthetic gene expression.

[UniProt]

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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