Thermo Fisher Scientific RWDD3 Monoclonal Antibody (OTI8B3), TrueMAB
RWDD3 단백질을 인식하는 Mouse monoclonal antibody로 Western Blot에 적합합니다. Human 시료에 반응하며, Lyophilized 형태로 제공됩니다. 재구성 후 약 1 mg/mL 농도로 사용 가능하며, PBS buffer(pH 7.3, 8% trehalose)로 안정화되어 있습니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8B3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–267 of human RWDD3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
RWDD3 (RSUME) is a small RWD-containing protein that enhances SUMO conjugation, playing a key role in the regulatory network of immune-inflammatory signaling.
It increases IκB sumoylation and stability, thereby inhibiting TNF-α-induced NF-κB activity and reducing expression of inflammatory genes such as IL-8 and COX-2.
RWDD3 expression is induced under hypoxic conditions and may play a role in vascularization. Both BMP-4 and RWDD3 are potential targets in pituitary tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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