Thermo Fisher Scientific CD6 (Negative Marker of T-regulatory Cells) Recombinant Rabbit Monoclonal Antibody (C6/7022R)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Immunoelectrophoresis (IE)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Antibody stability: 24 months
• Positive Control: MOLT-4, CCRF-CEM, Jurkat cells, human tonsil, or lymph node
• Cellular Localization: Cell surface, cytoplasm

Specificity Comments:
CD6 is a type I transmembrane glycoprotein with a 24-amino acid signal sequence, three extracellular SRCR domains, a membrane-spanning domain, and a 44-amino acid cytoplasmic domain. It becomes tyrosine phosphorylated during TCR-mediated T cell activation. CD6 is expressed on mature thymocytes, peripheral T cells, and a subset of B cells. Anti-CD6 antibodies are used to deplete T cells from bone marrow transplants to prevent graft-versus-host disease.

Target Information

CD6 (also known as T12) is a member of the scavenger receptor superfamily expressed on T and B cell subsets, thymocytes, and acute lymphocytic leukemia (ALL) cells. It interacts with CD166/ALCAM and functions as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM-mediated adhesion promotes T cell proliferation. CD6 may modulate CD5 signaling and has antiapoptotic roles in chronic lymphocytic leukemia B cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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