Thermo Fisher Scientific CD6 (Negative Marker of T-regulatory Cells) Recombinant Rabbit Monoclonal Antibody (C6/7022R)
CD6 단백질을 표적으로 하는 재조합 토끼 단일클론 항체로, T-regulatory 세포의 음성 마커 연구에 적합. IHC(P) 및 IHC(PFA) 실험에 최적화된 성능 제공. Human 시료 반응성, Protein A/G 정제, 보존제 무첨가 PBS 용액 형태.
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- 923-RBM7-P1ABX
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | C6/7022R |
| Immunogen | Human recombinant full-length CD6 protein (UniProt ID: P30203-1, amino acids 1–668) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD6 (also known as T12) is a member of the scavenger receptor superfamily expressed on T and B cell subsets, thymocytes, and acute lymphocytic leukemia (ALL) cells. It interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and functions as a coreceptor for T cell activation and stabilizer of the immunological synapse.
CD6-ALCAM mediated cell adhesion plays a role in T cell proliferation and may modulate CD5 signaling. Ligation of CD6 shows an anti-apoptotic effect in chronic lymphocytic leukemia B cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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