Thermo Fisher Scientific NFkB p65 Polyclonal Antibody
NFkB p65 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC 등 다양한 응용에 적합합니다. Human 및 Rat 시료에 반응하며, 합성 펩타이드 면역원 기반으로 제작되었습니다. -20°C 보관, 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2–4 µg/mL | - |
| Immunohistochemistry (IHC) | - | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20 | - |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Published species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to internal domain of human NFkappaB p65 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_10986349 |
Product Specific Information
PA5-16758 targets NFkappaB/p65 in IHC (P) and WB applications and shows reactivity with Human, Rabbit, and Rat samples.
The PA5-16758 immunogen is a synthetic peptide corresponding to internal domain of human NFkappaB p65.
Target Information
Nuclear factor kB p65 (NF-kB p65) is encoded by the RELA gene and is located on chromosome 11 in humans. NF-kB p65, also known as RelA, belongs to the Rel family of proteins and is one of the two subunits of NF-kB (Nuclear factor kappa-light-chain-enhancer of activated B cells). It heterodimerizes with other subunits such as p50 or p52.
Upon TNF-alpha binding to its receptor, IKK is phosphorylated and subsequently phosphorylates IκB, leading to proteasomal degradation of IκB. NF-kB p65 plays a key role in transcription of the immunoglobulin kappa (κ) gene in mature B-lymphoid cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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