Thermo Fisher Scientific Syk Polyclonal Antibody, Biotin
Syk 단백질을 표적하는 Thermo Fisher Scientific의 Biotin 결합 다클론 항체입니다. Western blot, IHC, ICC, ELISA 등 다양한 연구용 응용에 적합하며, 인간·마우스·랫트 반응성을 가집니다. 고순도 Affinity chromatography로 정제되어 안정적인 결과를 제공합니다.
- 카탈로그번호
- SYK-BIOTIN
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Syk Polyclonal Antibody, Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 100–150 on human Syk protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that serve as potential drug targets for allergic and autoimmune disorders. SYK may also play a role in cancer. Upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcεRI) activation, Syk translocates to the plasma membrane and phosphorylates downstream adaptor proteins, initiating signaling pathways such as calcium mobilization, cytoskeleton remodeling, and gene transcription. Syk interacts with receptor assemblies via its SH2 domains binding to ITAM motifs phosphorylated by Src-family kinases, which also activate Syk through phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(SYK-BIOTIN_Syk_P43405-1_Rabbit.svg 및 SYK-BIOTIN_Syk_P43405-1_Rabbit_PDP.jpeg)
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