Thermo Fisher Scientific Cardiotrophin 1 Polyclonal Antibody
마우스 Cardiotrophin-1(CT-1)을 인식하는 염소 폴리클로날 항체로, Western blot 및 중화 실험에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 동결건조 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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- PA547618
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Neutralization (Neu) | 0.08–0.48 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant mouse Cardiotrophin-1/CT-1 (Ser2–Ala203) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2607408 |
Product Specific Information
- In direct ELISAs and Western blots, approximately 40% cross-reactivity with recombinant human CT-1 is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
- Endotoxin level is <0.10 EU per 1 µg of antibody by the LAL method.
Target Information
Cardiotrophin-1 (CT-1) is a member of the IL-6 family of cytokines that signal through gp130 receptor complexes. gp130 complexes with several receptor subunits to transmit signals from Cardiotrophin-1, IL-6, LIF, OSM, CNTF, and IL-11.
Cardiotrophin-1 binds to and activates the leukemia inhibitory factor (LIF) receptor/gp130 receptor complex and can induce hypertrophy in cardiac myocytes in vitro.
It is a secreted protein expressed at high levels in myocardium during cardiogenesis and promotes proliferation and survival of embryonic cardiomyocytes, suggesting its role in gp130 activation during cardiac development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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