Thermo Fisher Scientific Urotensin II Receptor Polyclonal Antibody
Urotensin II 수용체를 인식하는 Rabbit Polyclonal 항체로, IHC(P) 적용 가능. Human 및 Non-human primate 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체이며, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
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- PA534299
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 6–11 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from N-terminal extracellular domain of human UTS2R / GPR14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551651 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey (100%).
Target Information
The Urotensin-II receptor (UTS2R) is highly expressed in the heart and pancreas, as well as in arteries and smooth muscle. Lower expression levels are found in the brain, particularly in the thalamus and superior occipital gyrus.
G-protein Coupled Receptors (GPCRs) represent one of the largest families of signaling molecules, characterized by seven transmembrane helices and existing in both active and inactive forms. Activation by specific ligands triggers G-protein signaling and downstream effectors.
GPCR regulation mechanisms are critical for cellular physiology and pharmacological research, leading to the development of major GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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