Thermo Fisher Scientific Urotensin II Receptor Polyclonal Antibody
Urotensin II 수용체를 인식하는 토끼 폴리클로날 항체로, 인간 시료에 반응합니다. IHC(P)에서 7–13 µg/mL로 사용됩니다. 항원 친화 크로마토그래피로 정제되었으며, 0.1% sodium azide가 포함된 PBS 용액 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) [IHC (P)]: 7–13 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from 1st cytoplasmic domain of human UTS2R / GPR14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551652 |
Target Information
The Urotensin-II receptor is highly expressed in the heart and pancreas, as well as in arteries and smooth muscle. Low transcript levels are found in the brain, particularly in the thalamus and superior occipital gyrus.
G-protein Coupled Receptors (GPCRs) form one of the largest families of signaling molecules, with over a thousand members predicted. These receptors share a structural motif of seven transmembrane helices and exist in active and inactive forms. Ligand binding induces conformational changes that trigger G-protein signaling and downstream effects.
Research continues to explore GPCR regulation and its role in pharmacology, with notable GPCR-targeted drugs including Zyprexa (Eli Lilly) and Claritin (Schering-Plough).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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