Thermo Fisher Scientific ZIP10 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ZIP10. Recombinant protein control fragment (Product #RP-96228). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ZIP10,uniProtId:Q9ULF5-1,ncbiNodeId:9606,antigenRange:156-252,antigenLength:831,antigenImageFileName:PA5-57697_ZIP10_Q9ULF5-1_Rabbit.svg,antigenImageFileNamePDP:PA5-57697_ZIP10_Q9ULF5-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649928

Product Specific Information

Immunogen sequence: EKETVEVSVK SDDKHMHDHN HRLRHHHRLH HHLDHNNTHH FHNDSITPSE RGEPSNEPST ETNKTQEQSD VKLPKGKRKK KGRKSNENSE VITPGFP

Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 65%.

Target Information

ZIP10, also known as Slc39A10, is a widely expressed zinc transporter with nine transmembrane domains. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP10 mRNA was found to be significantly decreased in the intestines and kidneys of hypothyroid rats and increased in those of hyperthyroid rats, indicating that ZIP10 is positively regulated by thyroid hormones. ZIP10 mRNA was also found to be upregulated in invasive and metastatic breast cancer and cell lines, suggesting that ZIP10 could serve as a possible marker for the metastatic phenotype and possibly a target for novel treatment strategies. At least three isoforms of ZIP10 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.