ELK Biotechnology Histamine H1 Receptor rabbit pAb
Histamine H1 Receptor rabbit polyclonal antibody for WB, IF, ELISA applications. Recognizes HRH1 protein in human, rat, and mouse. Targets peptide derived from human HRH1 (AA 141–190). High specificity, suitable for membrane protein detection and aller...
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Histamine H1 Receptor rabbit pAb
Supplier: ELK Biotechnology
제품 개요
Histamine H1 Receptor rabbit polyclonal antibody는 HRH1 단백질을 인식하는 항체로, Western blot, Immunofluorescence, ELISA 등 다양한 분석에 사용됩니다. 인간 HRH1 유래 합성 펩타이드(AA 141–190)를 면역원으로 제작되었습니다.
제품 스펙
| 항목 | 내용 |
|---|---|
| Product name | Histamine H1 Receptor rabbit pAb |
| Alternative Names | HRH1; Histamine H1 receptor; H1R; HH1R |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IF: 1/200–1/1000 ELISA: 1/10000 Other applications: Not tested |
| Immunogen | Synthesized peptide derived from human HRH1 (AA range: 141–190) |
| Host | Rabbit |
| Storage | −20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kDa |
| GeneID (Human) | 3269 |
| Human Swiss-Prot No | P35367 |
| Cellular Localization | Cell membrane; Multi-pass membrane protein |
| Species Reactivity | Human; Rat; Mouse |
Background
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its actions are mediated by histamine receptors H1, H2, H3, and H4. The protein encoded by HRH1 is an integral membrane protein belonging to the G protein-coupled receptor superfamily. It mediates smooth muscle contraction, increases capillary permeability, releases catecholamine from the adrenal medulla, and participates in neurotransmission in the central nervous system. HRH1 is linked to processes such as memory, learning, circadian rhythm, and thermoregulation, and contributes to allergic diseases including atopic dermatitis, asthma, anaphylaxis, and allergic rhinitis. Multiple alternatively spliced variants encoding the same protein have been identified.
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