ELK Biotechnology HDAC8 rabbit pAb
HDAC8 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 인간 유래 합성 펩타이드로 면역화되었으며, 핵 및 세포질에서 HDAC8 검출에 사용됩니다. 고순도 IgG, 1 mg/ml 농도로 제공됩니다.
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제품명
HDAC8 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | HDAC8; HDACL1; CDA07; Histone deacetylase 8; HD8 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HDAC8. AA range: 5-54 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 42 kDa |
| Gene ID (Human) | 55869 |
| Human Swiss-Prot No | Q9BY41 |
| Cellular Localization | Nucleus, Chromosome, Cytoplasm. Excluded from the nucleoli (PubMed:10748112). Found in the cytoplasm of cells showing smooth muscle differentiation (PubMed:15772115, PubMed:16538051). |
| Species Reactivity | Human; Mouse; Rat; Monkey |
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.
The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors.
Multiple transcript variants encoding different isoforms have been found for this gene.
[provided by RefSeq, Oct 2009]
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