ELK Biotechnology HDAC7 rabbit pAb
HDAC7 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 ELISA에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 핵과 세포질 내 HDAC7 단백질 검출에 사용됩니다. -20°C에서 1년간 보관 가능합니다.
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제품명
HDAC7 rabbit pAb
제품 개요
HDAC7 단백질을 인식하는 토끼 폴리클로날 항체입니다. Western blot과 ELISA 분석에 사용 가능하며, 인간, 마우스, 랫트 시료에서 반응합니다.
상세 정보
| 항목 | 내용 |
|---|---|
| Product name | HDAC7 rabbit pAb |
| Alternative Names | HDAC7; HDAC7A; Histone deacetylase 7; HD7; Histone deacetylase 7A; HD7a |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human HDAC7A (AA range: 121–170) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 103 kD |
| GeneID (Human) | 51564 |
| Human Swiss-Prot No | Q8WUI4 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus, Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on interaction with 14-3-3 protein YWHAE and phosphorylation. |
Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (RefSeq, Jul 2008)
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