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ELK Biotechnology HBO1 rabbit pAb
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HBO1 단백질을 인식하는 토끼 폴리클로날 항체로, WB, IF, ELISA에 적합합니다. 핵 및 염색체에 주로 위치하며 DNA 복제 및 전사 조절 연구에 활용됩니다. 인체, 마우스, 랫트 시료에 반응합니다.
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ELK Biotechnology ES2494-100UL HBO1 rabbit pAb, 100UL pk판매 단위 pk ·
재고 확인 필요
402,000원VAT 포함 442,200원
ELK Biotechnology ES2494-50UL HBO1 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology HBO1 rabbit pAb
제품명
HBO1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | KAT7; HBO1; HBOa; MYST2; Histone acetyltransferase KAT7; Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ; YBF2/SAS3, SAS2 and TIP60 protein 2; MYST-2 |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MYST2 (AA range: 131–180) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 75 kD |
| GeneID (Human) | 11143 |
| Human Swiss-Prot No | O95251 |
| Species Reactivity | Human; Mouse; Rat |
| Cellular Localization | Nucleus, Chromosome, Centromere, Cytoplasm (cytosol). Associates with replication origins during G1 phase. Localizes to transcription start sites and DNA damage sites after ATR phosphorylation. Also localizes to centromeres in G1 phase. |
Background
- Catalytic activity: Acetyl-CoA + histone = CoA + acetylhistone
- Domains:
- C2HC-type zinc finger required for interaction with MCM2 and ORC1L
- N-terminus involved in transcriptional repression
- C-terminus mediates AR interaction
- Function:
Component of the HBO1 complex with histone H4-specific acetyltransferase activity. Plays a role in chromatin acetylation, DNA replication, and TP53-dependent transcription coactivation. Represses AR-mediated transcription. - PTM: Phosphorylated upon DNA damage, likely by ATM or ATR
- Similarity:
- Belongs to the MYST (SAS/MOZ) family
- Contains one C2HC-type zinc finger
- Subunit:
Part of the HBO1 complex including ING4/ING5, MYTS2/HBO1, EAF6, and PHF15/16/17. Interacts with MCM2, ORC1L, and androgen receptor (AR) in presence of dihydrotestosterone. - Tissue specificity: Ubiquitously expressed, highest in testis
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