ELK Biotechnology Hairless rabbit pAb

ELK Biotechnology Hairless rabbit pAb

제품 설명

Hairless 단백질은 모발 성장에 관여하며, 여러 핵 수용체의 전사 억제 인자로 작용하는 단백질입니다. 본 항체는 인간 Hairless 단백질의 합성 펩타이드(AA 41–90)를 면역원으로 제작된 토끼 다클론 항체입니다. WB, IHC, IF, ELISA 등 다양한 실험에 적용 가능합니다.

제품 사양

Background

This gene encodes a protein involved in hair growth. The protein acts as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, retinoic acid receptor-related orphan receptors, and vitamin D receptor, interacting with histone deacetylases. Translation is regulated by an upstream open reading frame (ORF). Mutations in this ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant genetic hair loss disorder. Other mutations can lead to autosomal recessive congenital alopecia and atrichia with papular lesions. Two transcript variants encoding different isoforms have been identified.