ELK Biotechnology GSC2 rabbit pAb
GSC2 단백질을 인식하는 토끼 다클론 항체로, Western blot과 ELISA에 적합합니다. 인간 및 생쥐 시료에 반응하며, 핵에 위치한 GSC2 단백질 검출에 사용됩니다. 장기 보관 시 -20°C에서 1년 안정적입니다.
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제품명
GSC2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | GSC2; GSCL; Homeobox protein goosecoid-2; GSC-2; Homeobox protein goosecoid-like; GSC-L |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GSC2 (AA range: 131-180) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 25 kD |
| Gene ID (Human) | 2928 |
| Human Swiss-Prot No | O15499 |
| Cellular Localization | Nucleus |
| Species Reactivity | Human; Mouse |
Background
Goosecoid-like (GSCL), a homeodomain-containing gene, resides in the critical region for VCFS/DGS on chromosome 22q11. Velocardiofacial syndrome (VCFS) is a developmental disorder characterized by conotruncal heart defects, craniofacial anomalies, and learning disabilities. VCFS is phenotypically related to DiGeorge syndrome (DGS), and both syndromes are associated with hemizygous 22q11 deletions. Because many of the tissues and structures affected in VCFS/DGS derive from the pharyngeal arches of the developing embryo, it is believed that haploinsufficiency of a gene involved in embryonic development may be responsible for its etiology. The gene is expressed in a limited number of adult tissues, as well as in early human development. (Provided by RefSeq, Jul 2008)
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