ELK Biotechnology GluR-1 rabbit pAb
GluR-1 rabbit pAb은 인간 GluR1 유래 펩타이드로 제작된 폴리클로날 항체로, WB, IHC, IF, ELISA에 적합합니다. 신경세포 내 흥분성 신경전달 관련 Glutamate receptor 1 검출에 활용되며, 다양한 종(Human, Mouse, Rat)에 반응합니다.
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ELK Biotechnology GluR-1 rabbit pAb
제품 개요
GluR-1 rabbit pAb은 인간 GluR1 단백질에서 유래한 합성 펩타이드(AA 816–865)를 면역원으로 생산된 폴리클로날 항체입니다. Glutamate receptor 1을 검출하기 위한 연구용 항체로, 다양한 신경생리학적 과정에서 중요한 역할을 하는 수용체를 대상으로 합니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Product name | GluR-1 rabbit pAb |
| Alternative Names | GRIA1; GLUH1; GLUR1; Glutamate receptor 1; GluR-1; AMPA-selective glutamate receptor 1; GluR-A; GluR-K1; Glutamate receptor ionotropic; AMPA 1; GluA1 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 IF: 1/200–1/1000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human GluR1 (AA range: 816–865) |
| Host | Rabbit |
| Storage | −20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 95 kD |
| GeneID (Human) | 2890 |
| Human Swiss-Prot No | P42261 |
| Species Reactivity | Human; Mouse; Rat |
세포 내 위치
Cell membrane; Multi-pass membrane protein.
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Cell junction, synapse, postsynaptic density membrane; Multi-pass membrane protein.
Cell projection, dendrite; dendritic spine; early endosome membrane; recycling endosome membrane; presynapse.
Interaction with CACNG2, CNIH2, and CNIH3 promotes cell surface expression.
Colocalizes with PDLIM4 in early endosomes.
Displays somatodendritic localization and is excluded from axons in neurons.
Localized to cone photoreceptor pedicles (By similarity).
Background
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and participate in various normal neurophysiologic processes. These receptors form heteromeric protein complexes with multiple subunits arranged to create ligand-gated ion channels. The classification of glutamate receptors is based on activation by different pharmacologic agonists. This gene belongs to the AMPA receptor family (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate). Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
[Provided by RefSeq, Jul 2008]
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