ELK Biotechnology GCK rabbit pAb
GCK(Glucokinase) 단백질을 인식하는 토끼 폴리클로날 항체로 WB와 ELISA에 적합. 인간, 생쥐, 랫트 시료에 반응하며, 세포질 및 핵, 미토콘드리아에 위치한 단백질 검출에 활용 가능. -20°C에서 1년 보관 가능.
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ELK Biotechnology GCK rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | GCK rabbit pAb |
| Alternative Names | GCK; Glucokinase; Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GCK. AA range: 43-92 |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 55 kD |
| GeneID (Human) | 2645 |
| Human Swiss-Prot No | P35557 |
| Cellular Localization | Cytoplasm, Nucleus, Mitochondrion. Under low glucose concentrations, GCK associates with GCKR and the inactive complex is recruited to the hepatocyte nucleus. |
| Species Reactivity | Human; Mouse; Rat |
Background
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase — one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. Unlike other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active when glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity-onset diabetes of the young type 2 (MODY2), and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]
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