ELK Biotechnology GAD-65/67 rabbit pAb
GAD-65/67 rabbit pAb는 인간 및 생쥐 시료에서 GAD1/2 단백질을 검출하기 위한 polyclonal antibody입니다. WB, IHC, IF, ELISA에 사용 가능하며, 고감도 검출과 다양한 희석 조건을 지원합니다. -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
GAD-65/67 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | GAD1; GAD; GAD67; Glutamate decarboxylase 1; 67 kDa glutamic acid decarboxylase; GAD-67; Glutamate decarboxylase 67 kDa isoform; GAD2; GAD65; Glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 Immunofluorescence: 1/200 - 1/1000 ELISA: 1/5000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human GAD1/2 (AA range: 545–594) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kDa |
| Gene ID (Human) | 2571 / 2572 |
| Human Swiss-Prot No. | Q99259 / Q05329 |
| Cellular Localization | Intracellular, plasma membrane, vesicle membrane, presynaptic active zone, clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane |
| Species Reactivity | Human; Mouse |
Background
Glutamate decarboxylase 1 (GAD1) is one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. This enzyme catalyzes the conversion of L-glutamic acid to gamma-aminobutyric acid (GABA). It is implicated as an autoantigen and autoreactive T cell target in insulin-dependent diabetes and may also play a role in stiff man syndrome. Deficiency in this enzyme can lead to pyridoxine dependency with seizures. Alternative splicing results in two products: a predominant 67-kDa form and a less-frequent 25-kDa form.
(Provided by RefSeq, Jul 2008)
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