ELK Biotechnology FRS2 rabbit pAb
FRS2 rabbit pAb는 인간 FRS2 단백질을 인식하는 고품질 폴리클로날 항체로, WB 및 ELISA에 적합합니다. MAP kinase 활성화 관련 신호전달 연구에 활용되며, -20°C에서 1년간 안정적으로 보관 가능합니다.
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제품명
FRS2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | FRS2; Fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1; SNT-1 |
| Applications | WB; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 ELISA: 1/40000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human FRS2 (AA range: 162–211) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kD |
| GeneID (Human) | 10818 |
| Human Swiss-Prot No | Q8WU20 |
| Cellular Localization | Endomembrane system; Cytoplasmic, membrane-bound |
| Species Reactivity | Human; Mouse |
Background
Adapter protein that links FGFR and NGF receptors to downstream signaling pathways. Involved in activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Phosphorylated on tyrosine residues upon stimulation by NGF. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2; the unphosphorylated form is not subject to ubiquitination.
Contains one IRS-type PTB domain.
Part of complexes containing FRS2, GRB2, SOS1, and CBL. Binds RET (by similarity), FGFR1, SUC1, NTRK1, NTRK2, NTRK3, and SRC. The tyrosine-phosphorylated protein binds SH2 domains of GRB2 and PTPN11.
Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney, and testis.
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